Patrick J Battuello

Archive for the ‘Animal Experimentation’ Category

Pain in Animals

In Animal Experimentation, Animal Intelligence/Emotions on August 5, 2010 at 10:25 am

“Pain is pain regardless as to who or what suffers it. X amount of pain in a dog or a cat matters just as much as X amount of pain in a human being. It is the pain that matters, not the species.” (psychologist Richard Ryder)

“I personally can see no reason for conceding mind to my fellow men and denying it to animals. I at least cannot doubt that the interests and activities of animals are correlated with awareness and feeling in the same way as my own, and which may be, for aught I know, just as vivid.” (neurologist Russell Brain)

Sentience involves the ability to sense (feel) pleasure and pain. Many nonhuman species have the capacity for subjective feelings, including (but not limited to) affection, distress, fear, grief, and the negative experiences (anxiety, sadness) and symptoms (lethargy, compulsive actions) associated with neurosis. Still, there are some who accord sentience only to humans. This decidedly Cartesian viewpoint allows for a virtual carte blanche in the laboratory.

The International Association for the Study of Pain defines pain as “an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage. Note: The inability to communicate verbally does not negate the possibility that an individual is experiencing pain and is in need of appropriate pain-relieving treatment. Pain is always subjective….”

The requisite physiological mechanisms (nociceptors, spinal cord, brain) for pain are present in many nonhuman species. This is precisely why animal experimentation for human benefit is defended as useful. Animal tests, in fact, are conducted for the study of pain itself (and pain-relief medications). In addition, pain or distress indicators (writhing, contorting, moaning, vocalizing, avoiding) in animals are patently obvious (as are changes in vital signs). While true that an empirical analysis of a lab monkey’s pain eludes us, it is equally true that we cannot know with certainty what another human’s pain feels like.

As for emotional pain (lack of tissue damage), Dr. Lynne Sneddon (Liverpool University) writes:

Are animals capable of feeling emotional pain? Humans can certainly feel pain without physical damage – after the loss of a loved one, or the break-up of a relationship, for example. Some scientists suggest that only primates and humans can feel emotional pain, as they are the only animals that have a neocortex – the ‘thinking area’ of the cortex found only in mammals. However, research has provided evidence that monkeys, dogs, cats and birds can show signs of emotional pain and display behaviours associated with depression during painful experience, i.e. lack of motivation, lethargy, anorexia, unresponsiveness to other animals. Nevertheless, even if animal pain may be distinct from human pain, is that a reason to consider it less important either biologically or ethically?

The American Veterinary Medical Association on animal pain: “The AVMA believes that animal pain and suffering are clinically important conditions that adversely affect an animal’s quality of life. Drugs, techniques, or husbandry methods used to prevent and control pain must be tailored to individual animals…” And the European Union added a Protocol on the Protection and Welfare of Animals to the Treaty of Amsterdam in 1997: “…to ensure improved protection and respect for the welfare of animals as sentient beings…”

Society, through the Humane Slaughter Act, Animal Welfare Act, and state anti-cruelty laws, acknowledges that animals can experience pain and suffering. The USDA requires annual reports from laboratories on how many animals were used in pain-causing experiments and whether anesthetics and analgesics were administered (Column E). If pain were irrelevant, then why would contemporary science even bother with reduction, refinement, replacement? Clearly, then, pain, distress, and suffering exist in other beings. And if Dr. Ryder is right when he says that pain “is the great evil, and inflicting pain upon others is the only wrong,” then we have a moral obligation to stop causing animal pain, even if doing so may slow medical progress (a dubious claim anyhow).

Stealing Organs: The Immorality of Xenotransplantation

In Animal Experimentation, Baboons, Monkeys, Pigs, Xenotransplantation on August 4, 2010 at 11:04 am

“We have to be frank about this: We are exploiting these pigs.” (Dr. David White, former director of research at Imutran in England)

“Generally speaking, our society and our government is at least giving the impression that it’s becoming more sensitive to the welfare needs of animals and we all hope that sensitivity and compassion will develop. But with xenotransplantation, it’s a sort of massive blow to that sense of progression. It’s a step into the Dark Ages. It may look really nice and scientific and clean, but in terms of what we’re actually doing to animals, it’s barbaric.” (Dr. Dan Lyons, expert on British animal research policy)

Xenotransplantation is the transfer of cells, tissues, or whole organs from one species to another. More specifically, animal parts harvested for the good of humanity. The technology is not, at present, practical. Xenozoonoses (infectious diseases transmitted to the recipient, perhaps an AIDS II), hyperacute rejection (the immune system attacking the new organ as foreign), and infections (the immunosuppressive drugs, designed to combat rejection, leave the body susceptible) are not so insignificant hurdles.

The first kidney xenografts (from chimps) were reported in 1963, and a year later the first heart (chimp again) was xenotransplanted. The longest cardiac success came in 1984 with the Baby Fae case. Baby Fae received a baboon heart at infancy and survived for three weeks. Ironically, Time ran an essay by Charles Krauthammer in which he decried the exploitation of the baby (the surgeons, knowing it would fail, used her as a guinea pig), not the baboon. In 1984, the modern animal rights movement was in its nascent stage. There were protests, but the debate was largely over Baby Fae’s dignity and the biological integrity of the human race.

In the late 1990’s, Imutran (a subsidiary of Novartis, the pharmaceutical giant) conducted grisly experiments at the Huntingdon Life Sciences laboratories in England. The scientists grafted genetically-modified (to create a human-like organ) pig hearts into baboons and cynomolgus monkeys. The goal was twofold: first, a marketable xenograft for human use; and second, development of the critical immunosuppressants (hence, Novartis funding the research). Internal documents were leaked to the animal rights group Uncaged Campaigns in early 2000, and a report detailing the research (Imutran sued to block and lost) soon followed.

The 50 or so baboons were kidnapped in Africa, and the 400-600 monkeys were purchased from Asian breeders and transported to England in small metal cages. Most of the baboons had pig hearts transplanted into their necks and abdomens (i.e., not life-supporting). The majority of the monkeys had their own kidneys removed and replaced with one pig kidney (they were life-supporting but abnormally positioned). All of the animals died. The documents revealed collusion between the British government and Imutran to suppress troublesome details. These descriptions of post-surgery come directly from the researchers’ logs:

quiet and huddled…body and head tremors…large vomit in cage…exhibits discomfort when moving…no use of right arm…right arm badly swollen and bruised…skin broken and oozing blood…collapsed on cage floor…very laboured breathing…extreme difficulty trying to walk…holding neck…animal picking at transplant site…keeps holding area where transplanted heart is…yellow fluid seeping from site…animal showing obvious discomfort…uncoordinated limb spasms…retching and salivating…bloody discharge from penis…observed shivering…periodic severe tremors…extreme difficulty breathing, vocalising…died prior to sacrifice…sacrificed for humane reasons

While some died from technical failures within 24 hours, most lingered for 13-99 days before succumbing to infection, rejection, or toxicity. Imutran’s research was discontinued (and moved to the U.S.) largely as a result of Uncaged’s disclosure. In an interview with Frontline, Dan Lyons said: “One of the most unfortunate animals had a piglet heart transplanted into his neck. …for several days he was holding the heart. It was swollen. It was seeping blood, it was seeping pus… He suffered from body tremors, vomiting, diarrhea. And the animal just sat there. I think living hell is really the only sort of real way you can get close to describing what it must be like to have been that animal in that situation.”

In order to produce workable xenografts, the above cited experiments are necessary. Armed with that knowledge, we must ask: How much suffering and destruction is acceptable in the pursuit of medical progress? For me, the answer is simple. The exploitation of the weak and the voiceless is always immoral, no matter the species. We do not harvest the organs of small children or the mentally enfeebled (i.e., those intellectually comparable to apes and pigs) because they are us. Speciesism defined. Other sentient beings are not resources to be carved and plucked. Support mechanical devices, become an organ donor, and bequeath your body to education. That is the least we can do.

The Cle Elum Seven

In Animal Experimentation, Chimpanzees on August 4, 2010 at 1:40 am

They were once just numbered research material sentenced to a hellish existence inside tiny cages at nondescript, windowless laboratories. Their lives meant nothing beyond their value (to human beings) as test subjects. Given our genetic connection with chimpanzees, is it that difficult to imagine (empathize with) their sadness? Their helplessness? A sadness and helplessness, by the way, measured in decades. A sadness and helplessness sometimes descending into madness. Now, though, we can call them a family:

Annie
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Burrito
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Foxie
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Jamie
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Jody
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Missy
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Negra
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They live among friends at Chimpanzee Sanctuary Northwest (CSNW) near Seattle. CSNW was founded by Keith LaChappelle (with his $200,000 life’s savings) in 2003 after he read an article about research chimps. Keith told Seattle Met Magazine, “It talked about how a lot of chimpanzees aren’t actively being used for research, but they’re still languishing in these five-by-five lab cages because there’s nowhere for them to go.” While visiting other sanctuaries (at one, he looked into the eyes of a chimp who had endured 50 biopsies and knew what must be done), LaChappelle met Sarah Baeckler (see Chimps on (and off) Stage), and they decided to join forces (along with Diana Goodrich and J.P. Mulcahy). It so happened that seven chimpanzees were rotting away in a basement pen at Buckshire in Pennsylvania (a business that leased animals for laboratory testing). LaChappelle says, (Seattle Times, 8/25/08) “The…idea of these individuals stuck in a cage, with nowhere to go, and to keep them in those cages for decades… I just couldn’t imagine that. Chimps have self-awareness and understand where they’re at.”

There are at least 1,000 chimpanzees withering in American laboratories (and roughly 600 in 10 American/Canadian sanctuaries). There is a pending bill in Congress (the Great Ape Protection Act) that would prohibit invasive procedures on all great apes and provide for the permanent retirement of those who are federally-owned (the estimated 500 who belong to us). Public sentiment is trending towards a quasi-legal recognition of our closest cousins.

The evil that has been visited upon laboratory chimps is unconscionable. The painful procedures, will-breaking confinement, psychological abuse, and emotional trauma (which often includes severing the mother-child bond) cannot be defended, no matter the benefits gained.

Primatologist Debra Durham is studying the effects of trauma on chimpanzees who have been imprisoned for most of their lives. She writes: “The United States is the only nation in the world to continue using chimpanzees in large-scale invasive experiments. Even in America, many chimpanzees in laboratories are essentially warehoused, no longer used in active protocols because they haven’t proved useful as models for human diseases, but still kept in laboratory cages.” One such chimp was Jeannie. Her story is profoundly sad.

49_jean_chimpanzee-LEMSIP

These wonderful, beautiful beings, once rescued, should be sterilized (which appears to be sanctuary norm). The bastardization of their species should end with this generation. For now, the good people at CSNW deserve our admiration, gratitude, and respect. Though hoping to provide a measure of happiness after the storm, LaChappelle cautions, “It’s not retirement. They’re really still captive chimpanzees. It’s dignity. We’re giving them dignity.” Please encourage your congressperson to support HR1326. Please, also, consider sponsoring a chimp at CSNW (or any other sanctuary). It’s the least we can do.

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